3-Substituted Thiophenes. V. Alkamine Esters of Phenyl-3-thienylglycolic Acid1

E Campaigne, RC Bourgeois

Index: Campaigne; Bourgeois Journal of the American Chemical Society, 1953 , vol. 75, p. 2702

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Citation Number: 12

Abstract

JOURNAL. 71, 4012 (1949). for the clinically useful antispasmodic drug, Trasentin (P- diethylaminoethyl diphenylacetate). Blicke and Tsao6 prepared phenyl-2-thienylglycolic acid in two ways: by the reaction of phenylmagnesium bromide with 2-thienylglyoxylic acid, and by the reaction of 2-thienylmagnesium bromide on phenylglyoxylic acid. Neither of these methods can be readily applied in the 3-thiophene series because of the difficulty of ...