Synthesis of 2??(2′, 3′??dihydroxypropyl)??5??amino??2H??1, 2, 4??thiadiazol??3??one and 3??(2′, 3′??dihydroxypropyl)??5??amino??3H??1, 3, 4??thiadiazol??2??one

C Párkányi, HL Yuan, NS Cho, JHJ Jaw…

Index: Parkanyi, Cyril; Yuan, Hui Liang; Cho, Nam Sook; Jaw, JIn-Hwa J.; Woodhouse, Tamar E.; Aung, Thomas L. Journal of Heterocyclic Chemistry, 1989 , vol. 26, p. 1331 - 1334

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Citation Number: 31

Abstract

Abstract The synthesis of two new acyclic nucleoside analogs, 2-(2′, 3′-dihydroxypropyl)- 5-amino-2H-1, 2, 4-thiadiazol-3-one (1) and 3-(2′, 3′-dihydroxypropyl)-5-amino-3H-1, 3, 4- thiadiazol-2-one (2), is reported. The first compound, 1, was obtained by reaction of 3-chloro- 1, 2-propanediol with the sodium salt of 5-amino-2H-1, 2, 4-thiadiazol-3-one (3) in anhydrous dimethylformamide. Similarly, 5-amino-3H-1, 3, 4-thiadiazol-2-one (4) reacted ...

5-imino-1, 2, 4-thiadiazoles: first small molecules as substrate competitive inhibitors of glycogen synthase kinase 3

[Castro, Ana; Encinas, Arantxa; Gil, Carmen; Braese, Stefan; Porcal, Williams; Perez, Concepcion; Moreno, Francisco J.; Martinez, Ana Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 1 p. 495 - 510]

Reaction of S-methiodide derivatives of activated thioureas with hydroxylic compounds. Novel synthesis of mercaptans

[Klayman,D.L. et al. Journal of Organic Chemistry, 1972 , vol. 37, p. 1532 - 1537]

Synthesis of 2??(2′, 3′??dihydroxypropyl)??5??amino??2H??1, 2, 4??thiadiazol??3??one and 3??(2′, 3′??dihydroxypropyl)??5??amino??3H??1, 3, 4??thiadiazol??2??one

Abstract

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