Remarkable Effect of D-Sorbitol on the Second Stage in the PLE-Catalyzed Hydrolyses of a. SIGMA.-Symmetric Diester, cis-Cyclohex-4-ene-1, 2-bis (methyl acetate).
Y Nagao, T Tohjo, T Kaneuchi, Y Yukimoto, M Kume
Index: Nagao, Yoshimitsu; Tohjo, Toshiaki; Kaneuchi, Tohru; Yukimoto, Yusuke; Kume, Masaharu Chemistry Letters, 1992 , # 9 p. 1817 - 1820
Full Text: HTML
Citation Number: 5
Abstract
Enantioselective hydrolysis of cis-cyclohex-4-ene-1, 2-bis (methyl acetate) with porcine liver esterase (PLE) in the presence of D-sorbitol afforded a chiral monoester in a highly enantioselective manner. During the enzymatic hydrolyses, D-sorbitol efficiently accelerate the second stage; hydrolysis of the resultant minor monoester toward the dicarboxylic acid leaving the desired major monoester.
Related Articles:
Reduction of cis-bicyclo [4.3. 0] non-3-ene and its 8-substituted heterocyclic analogs
[Mundy,B.P.; Theodore,J.J. Journal of the American Chemical Society, 1980 , vol. 102, p. 2005]
[Paquette,L.A. et al. Journal of the American Chemical Society, 1973 , vol. 95, p. 2230 - 2240]
[Nagao, Yoshimitsu; Ikeda, Takao; Inoue, Takehisa; Yagi, Masahiro; Shiro, Motoo; Fujita, Eiichi Journal of Organic Chemistry, 1985 , vol. 50, # 21 p. 4072 - 4080]
[Nagao, Yoshimitsu; Ikeda, Takao; Inoue, Takehisa; Yagi, Masahiro; Shiro, Motoo; Fujita, Eiichi Journal of Organic Chemistry, 1985 , vol. 50, # 21 p. 4072 - 4080]