Exploitation of a Candida antarctica lipase B-catalysed in situ carboxylic acid activation method for the synthesis of acetanilides
S Lal, TJ Snape
Index: Lal, Samridhi; Snape, Timothy J. Journal of Molecular Catalysis B: Enzymatic, 2012 , vol. 83, p. 80 - 86
Full Text: HTML
Citation Number: 4
Abstract
An efficient biocatalytic method has been developed which provides acetanilides in good yields which are otherwise inaccessible using Candida antarctica lipase B. The process exploits the enzyme-catalysed synthesis of an acyl donor and its in situ reaction with anilines. The method is potentially useful for the synthesis of bulky acetanilides since amide formation occurs through an active site-independent step.
Related Articles:
[Veisi, Hojat; Ghorbani-Vaghei, Ramin; Eskandari, Hosna; Hemmati, Saba; Rezaei, Ardashir; Hajinazari, Somaye; Far, Mohammad Raoof Heidari; Entezari, Azam Phosphorus, Sulfur and Silicon and the Related Elements, 2011 , vol. 186, # 2 p. 213 - 219]
A novel and efficient oxidation of 1, 2-amino alcohols to dialkylamides
[Garcia-Valverde, Maria; Pedrosa, Rafael; Vicente, Martina Synlett, 2002 , # 12 p. 2092 - 2094]
A novel SN1 displacement: The reaction of tertiary amines with acetic anhydride
[Khai, Bui The; Arcelli, Antonio Journal of Organometallic Chemistry, 1983 , vol. 252, # 1 p. C9 - C13]
Thioacids Mediated Selective and Mild N-Acylation of Amines
[Taylor, James E.; Jones, Matthew D.; Williams, Jonathan M. J.; Bull, Steven D. Journal of Organic Chemistry, 2012 , vol. 77, # 6 p. 2808 - 2818]
N-Alkylierung von Carbonsäure-amiden
[Isele,G.I.; Luettringhaus,A. Synthesis, 1971 , p. 266 - 268]