Tetrahedron

Tributylphosphine, excellent organocatalyst for conjugate additions of non-nucleophilic N-containing compounds

C Gimbert, M Moreno-Mañas, E Pérez, A Vallribera

Index: Gimbert, Carolina; Moreno-Manas, Marcial; Perez, Elisabet; Vallribera, Adelina Tetrahedron, 2007 , vol. 63, # 34 p. 8305 - 8310

Full Text: HTML

Citation Number: 39

Abstract

Conjugate additions of non-nucleophilic N-containing compounds such as amides, thioamides, sulfonamides, and electron-poor anilines with different Michael acceptors can be promoted through the use of tributylphosphine. The range of useful pKa's of nucleophiles has been established (pKa< 25) and new insights into the mechanism proposed.