Structure and antiinflammatory activity of isonicotinic and nicotinic amides

…, VF Danilenko, GI Danilenko, VM Ovrutskii…

Index: Bukhtiarova; Trinus; Danilenko; Ovrutskii; Sharykina Pharmaceutical Chemistry Journal, 1998 , vol. 32, # 11 p. 597 - 599

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Citation Number: 6

Abstract

It was suggested that butadion and indomethacin, the de- rivatives of anthranilic acid, are capable of competitively in- teracting with receptors or enzymatic systems involved in the synthesis, deposition, or release of histamine and serotonin from their depots in tissues. This conclusion was based on the fact that the distance between the carboxy or enolic group and the second reaction center (hydroxy or amino group) in mole- cules of these antiinflammatory drugs ( ...