Synthesis and antitumor activity of simple vinyl and. alpha.-methylene-. gamma.-butyrolactone sulfonate esters and silyl enol ethers

PJ Stang, WL Treptow

Index: Stang, Peter J.; Treptow, Warren L. Journal of Medicinal Chemistry, 1981 , vol. 24, # 4 p. 468 - 472

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Citation Number: 30

Abstract

A number of simple silyl enol ethers and vinyl trifluoromethanesulfonatea, a relatively new class of organic compounds capable of undergoing alkylation by a nucleophilic addition- elimination prows, were evaluated in the P388 lymphocytic leukemia system. No activity (ILS= 8-22%) was observed in the simple vinyl derivatives. Some activity (ILS= 20-42%) was observed for a series of siloxy and sulfonate (CH3S02 and CF a O a functionalized a- ...