Synthesis of novel benzamidine-and guanidine-derived polyazamacrocycles: Selective anti-protozoal activity for human African trypanosomiasis

…, C Ebikeme, MP Barrett, EM Patzewitz, S Müller…

Index: Reid, Caroline M.; Ebikeme, Charles; Barrett, Michael P.; Patzewitz, Eva-Maria; Mueller, Sylke; Robins, David J.; Sutherland, Andrew Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 20 p. 5399 - 5401

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Citation Number: 12

Abstract

Efficient synthetic routes have been developed for the preparation of two new polyazamacrocycles tagged with structural motifs recognised by the Trypanosoma brucei P2 aminopurine transporter. Biological testing of these compounds showed highly selective anti- protozoal activity against trypanosomes.