Helvetica Chimica Acta

Convenient Synthesis of Various Substituted Homotaurines from Alk??2??enamides

Y Nai, J Xu

Index: Nai, Youfeng; Xu, Jiaxi Helvetica Chimica Acta, 2013 , vol. 96, # 7 p. 1355 - 1365

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Abstract

Abstract Various substituted homotaurines (= 3-aminopropane-1-sulfonic acids) 6 were readily synthesized in satisfactory to good yields via the Michael addition of thioacetic acid to alk-2-enamides 3 ([RIGHTWARDS ARROW] 4), followed by LiAlH 4 reduction

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