Amino acids

Resolution of protected silaproline for a gram scale preparation

…, N Vanthuyne, H Miramon, J Martinez, F Cavelier

Index: Martin; Vanthuyne; Miramon; Martinez; Cavelier Amino Acids, 2012 , vol. 43, # 2 p. 649 - 655

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Citation Number: 6

Abstract

Abstract Silaproline is an analogue of proline, which exhibits similar conformational properties. Moreover, the presence of dimethylsilyl group confers to silaproline a higher lipophilicity as well as an improved resistance to biodegradation. This report describes the comparison of two routes to obtain Fmoc-(l) Sip-OH on the gram scale using chiral HPLC resolution.