Desulfitative Carbon–Carbon Cross??Coupling of Thioamide Fragments with Boronic Acids

H Prokopcova, CO Kappe

Index: Prokopcova, Hana; Kappe, C. Oliver Advanced Synthesis and Catalysis, 2007 , vol. 349, # 3 p. 448 - 452

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Citation Number: 43

Abstract

Abstract A novel and general carbon–carbon cross-coupling reaction between cyclic thioamides and boronic acids is described. The reaction is catalytic in palladium (0) and requires stoichiometric amounts of a copper (I) carboxylate as metal cofactor. The mode of cross-coupling in the reaction of cyclic thioamides with boronic acids is easily tunable between carbon–carbon and carbon–sulfur cross-coupling. While the catalytic palladium ( ...