An innovative strategy for the synthesis of a new series of potent aminopeptidase (APN or CD13) inhibitors derived from the oxepin-4-one family

…, C Charrier, E Salomon, M Ilhan, P Bisseret, C Tarnus

Index: Roux, Lionel; Charrier, Cedric; Salomon, Emmanuel; Ilhan, Meral; Bisseret, Philippe; Tarnus, Celine Tetrahedron Letters, 2011 , vol. 52, # 20 p. 2586 - 2589

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Citation Number: 3

Abstract

Abstract Derivatives from the aminobenzosuberone family have been recently synthesized and recognized as highly selective inhibitors of aminopeptidase N (APN)/CD13 (EC 3.4. 11.2), an important target for cell migration processes involved in particular in tumor invasion. We present here a much more straightforward synthesis of analogues belonging to a novel isosteric oxo series which also possesses excellent inhibitory potential against ...