Journal of Fluorine Chemistry

Synthesis and antimicrobial activity of some novel 2-(substituted fluorobenzoylimino)-3-(substituted fluorophenyl)-4-methyl-1, 3-thiazolines

A Saeed, U Shaheen, A Hameed, F Kazmi

Index: Saeed, Aamer; Shaheen, Uzma; Hameed, Abdul; Kazmi, Faiza Journal of Fluorine Chemistry, 2010 , vol. 131, # 3 p. 333 - 339

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Citation Number: 19

Abstract

The synthesis of several 2-(substituted fluorobenzoylimino)-3-(substituted fluorophenyl)-4- methyl-1, 3-thiazolines (2a–t) was carried out by base-catalyzed cyclization of corresponding 1-(fluorobenzoyl)-3-(fluorophenyl) thioureas (1a–t) with 2-bromoacetone in aqueous medium. The structures of the synthesized compounds were confirmed by spectral and elemental analysis. All synthesized compounds were evaluated for in vitro ...