The Journal of organic chemistry

Convergent Synthesis of (2 R, 3 R, 8 R, 9 R)-N-Boc-ADDA

S Meiries, R Marquez

Index: Meiries, Sebastien; Marquez, Rodolfo Journal of Organic Chemistry, 2008 , vol. 73, # 13 p. 5015 - 5021

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Citation Number: 18

Abstract

The convergent synthesis of N-Boc-(2 R, 3 R, 8 R, 9 R, 4 E, 6 E)-3-amino-9-methoxy-2, 6, 8- trimethyl-10-phenyldecadenoic acid (enantio-N-Boc-ADDA) is reported. Our flexible approach takes advantage of highly efficient non-aldol aldol and cross-metathesis methodologies.