Reversible and in situ formation of organic arsenates and vanadates as organic phosphate mimics in enzymatic reactions: mechanistic investigation of aldol reactions …

…, JR Durrwachter, RL Pederson, DC Crans…

Index: Drueckhammer, Dale G.; Durrwachter, J. Robert; Pederson, Richard L.; Crans, Debbie C.; Daniels, Lacy; Wong, Chi-Huey Journal of Organic Chemistry, 1989 , vol. 54, # 1 p. 70 - 77

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Citation Number: 95

Abstract

A synthetic strategy is developed that uses organic phosphate utilizing enzymes as catalysts and a mixture of an organic alcohol and inorganic arsenate or vanadate to replace the organic phosphate substrate. In this process, inorganic arsenate or vanadate reacts with the alcohol reversibly in situ to form a mixture of esters, one of which is accepted by the enzyme as a substrate. Examples of the utility of this approach are demonstrated in enzymatic ...