Nucleophile??Catalyzed Asymmetric Acylations of Silyl Ketene Imines: Application to the Enantioselective Synthesis of Verapamil

AH Mermerian, GC Fu

Index: Mermerian, Ara H.; Fu, Gregory C. Angewandte Chemie - International Edition, 2005 , vol. 44, # 6 p. 949 - 952

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Citation Number: 87

Abstract

Generating enantiomerically enriched nitriles in which the cyano group is bound to an all- carbon quaternary stereocenter (eg 1) is an important challenge in synthetic organic chemistry and is owed in part to the biological activity of such compounds.[1] We have recently turned our attention to the development of catalytic asymmetric methods that address this challenge [2, 3] by focusing on reactions of nitrile anions.[4] Such species are ...