Cyanocuprates convert carboxylic acids directly into ketones
DT Genna, GH Posner
Index: Genna, Douglas T.; Posner, Gary H. Organic Letters, 2011 , vol. 13, # 19 p. 5358 - 5361
Full Text: HTML
Citation Number: 25
Abstract
Carboxylic acids were converted directly in 56–99% yields into methyl, n-butyl, and isopropyl ketones using excess cyanocuprates R2CuLi· LiCN. A substrate with a stereocenter α to the carboxylic acid was converted into ketones with very little loss of enantiomeric purity. A variety of functional groups were tolerated including aryl bromides. This direct transformation of a carboxylic acid into ketone with minimal tertiary alcohol ...
Related Articles:
An effective one-pot conversion of acid chlorides to aldehydes and ketones
[Park, Jae Kyo; Shin, Won Kyu; An, Duk Keun Tetrahedron Letters, 2013 , vol. 54, # 24 p. 3199 - 3203]
Contribution a L'Étude de la Clathration: Synthése et Propriétés des α??Arylalcoylamines I
[de Roocker,A.; de Radzitzky,P. Bulletin des Societes Chimiques Belges, 1963 , vol. 72, p. 202 - 207]
[Satoh, Tsuyoshi; Itoh, Norifumi; Gengyo, Kaoru; Takada, Sae; Asakawa, Naoyuki; et al. Tetrahedron, 1994 , vol. 50, # 41 p. 11839 - 11852]