Solvent-free Mukaiyama aldol reaction of O-silyl dienolates catalyzed by benzoic acid
MR Acocella, A Massa, L Palombi, R Villano, A Scettri
Index: Acocella, Maria Rosaria; Massa, Antonio; Palombi, Laura; Villano, Rosaria; Scettri, Arrigo Tetrahedron Letters, 2005 , vol. 46, # 36 p. 6141 - 6144
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Citation Number: 16
Abstract
The vinylogous aldol reaction of O-silyl dienolates deriving from 2, 2-dimethyl-[1, 3]-dioxin-4- ones proceeds in moderate to excellent yields in the presence of catalytic amounts of PhCOOH under solvent-free conditions. Modest to good yields can be obtained by using silica gel or 3Å molecular sieves as heterogeneous catalysts.
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