Tetrahedron letters

Improved protective groups for phosphate of o-phosphoserine useful for the solid-phase peptide synthesis

M Tsukamoto, R Kato, K Ishiguro, T Uchida, K Sato

Index: Tsukamoto, Masamitsu; Kato, Rika; Ishiguro, Koichi; Uchida, Tsuneko; Sato, Kazuki Tetrahedron Letters, 1991 , vol. 32, # 48 p. 7083 - 7086

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Citation Number: 27

Abstract

Abstract 2-Methylphenyl and 2, 6-dimethylphenyl groups on phosphate moiety of O- phosphoserine were more stable in HF treatment than phenyl group and could be effectively removed by hydrogenolysis. They were shown to be protective groups for phosphoserine practically applicable in the Boc/Bzl mode of solid-phase peptide synthesis.