Synthesis and biological activities of pyrazolo [3, 4-g] quinoxaline derivatives

…, G Alves, E Debiton, F Anizon, P Moreau

Index: Gavara, Laurent; Saugues, Emmanuelle; Alves, Georges; Debiton, Eric; Anizon, Fabrice; Moreau, Pascale European Journal of Medicinal Chemistry, 2010 , vol. 45, # 11 p. 5520 - 5526

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Citation Number: 27

Abstract

The synthesis of new pyrazolo [3, 4-g] quinoxaline derivatives, as well as their Pim kinases (Pim-1, Pim-2, Pim-3) inhibitory potencies and in vitro antiproliferative activities toward a human fibroblast primary culture and three human solid cancer cell lines (PA1, PC3 and DU145) are described. The results obtained in this preliminary structure–activity relationship study have pointed out that most of the compounds in this series exhibited interesting in ...