Deracemisation of α??chiral primary amines by a one??pot, two??step cascade reaction catalysed by ω??transaminases
D Koszelewski, D Clay, D Rozzell…
Index: Koszelewski, Dominik; Clay, Dorina; Rozzell, David; Kroutil, Wolfgang European Journal of Organic Chemistry, 2009 , # 14 p. 2289 - 2292
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Citation Number: 50
Abstract
Abstract Racemic α-chiral primary amines were deracemised to optically pure amines in up to> 99% conversion and> 99% ee within 48 h. The deracemisation was a result of a stereoinversion of one amine enantiomer; the formal stereoinversion was achieved by a one- pot, two-step procedure: in the first step, kinetic resolution of the chiral racemic amine was performed by employing a ω-transaminase to yield an intermediate ketone and the ...
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