Isonicotinoylhydrazothiazoles and isonicotinoyl??N4??substituted thiosemicarbazides: Synthesis, characterization, and anti??mycobacterial activity

…, S Distinto, E Maccioni, A Plumitallo…

Index: Cardia, Maria Cristina; Distinto, Simona; Maccioni, Elias; Plumitallo, Antonio; Saddi, Manuela; Sanna, Maria Luisa; DeLogu, Alessandro Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 5 p. 1337 - 1342

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Citation Number: 15

Abstract

Introduction. Since the discovery of Streptomycin, an increasing effort has been devoted to the development of new and more efficient anti-tubercular agents, leading to the introduction of a number of new molecules in clinical practice [1 – 12]. Nevertheless the growth of multi-drug resistant mutant species of mycobacterium (MDR) has become an emerging problem [13], in spite of the fact that M. tuberculosis was one of the first infective agents whose genome was ...