J. Chem. Soc. Pakistan

Spectrophotometric Determination of pK (a)'s of 1-Hydroxybenzotriazole and Oxime Derivatives in 95% Acetonitrile-Water

MF Fathalla, SN Khattab

Index: Fathalla, Magda Fouad; Khattab, Sherine Nabil Journal of the Chemical Society of Pakistan, 2011 , vol. 33, # 3 p. 324 - 332

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Citation Number: 14

Abstract

Summary: 1-hydroxybenzotriazole derivatives are used with carbodiimide as additives to generate active esters during peptide bond formation. They are also used as additives during the peptide bond formation. Dissociation constants of the 1-hdroxybenzotriazole (HOBt) and its derivatives, 1-hydroxy-6-chlorobenzotriazole, 1-hydroxy-6- trifluoromethylbenzotriazole, 1-hydroxy-6-nitrobenzotriazole were determined ...