Hydroxypropylation

PE Eaton, GF Cooper, RC Johnson…

Index: Eaton,P.E. et al. Journal of Organic Chemistry, 1972 , vol. 37, p. 1947 - 1950

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Citation Number: 79

Abstract

We recently faced the problem of finding a convenient method for the introduction of the hydroxypropyl group,-CH2CH2CH20H, via organometallic-type reactions. Surprisingly, little in the literature is applicable to this problem. Grignard reagents from methyl, ethyl, 2 and tert- amyl3 ethers of 3-bromopropanol have been used in reactions with carbonyl compounds, but subsequent liberation of the primary hydroxyl group from its protecting ether mask ...