Synthesis of diaminodideoxyalditol analogs of cisplatin as antitumor agents

S Hanessian, JY Gauthier, K Okamoto…

Index: Hanessian; Gauthier; Okamoto; Beauchamp; Theophanides Canadian Journal of Chemistry, 1993 , vol. 71, # 6 p. 880 - 885

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Citation Number: 18

Abstract

Acyclic vicinal polyol complexes related to cisplatin were synthesized from d-mannitol by stereocontrolled manipulation of the hydroxy groups. Controlled cleavage of a 3, 4-diazido hexitol gave the corresponding d-threitol and d-xylitol analogs, which were converted to their diamino platinum complexes. The antitumor activity of these compounds is reported.