An anomalous Eschweiler-clarke reaction

S Rahal, L Badache

Index: Rahal, Said; Badache, Leila Tetrahedron Letters, 1991 , vol. 32, # 31 p. 3847 - 3848

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Citation Number: 10

Abstract

Conditions: 0.3 mol. of amino-acid, 65 ml of 37−40% HCHO and 75 ml of 90% HCO 2 H are refluxed until CO 2 evolution ceases (6−17h). 30 ml concentrated HC1 is added and the solution evaporated under reduced pressure. The resulting N,N-dimethylaminoacid hydrochlorides are crystallized in an ethanol/acetone mixture. Treatment of the hydrochlorides with an equivalent quantity of freshly pricipitated silver oxide (ref.8), filtering and evaporating to dryness leads to the ...