17β-Estradiol nitration by peroxidase/H 2 O 2/NO 2−: a chemical assessment

…, R Boni, A Napolitano, A Palumbo, M d'Ischia

Index: Pezzella, Alessandro; Manini, Paola; Di Donato, Paola; Boni, Raffaele; Napolitano, Alessandra; Palumbo, Anna; d'Ischia, Marco Bioorganic and medicinal chemistry, 2004 , vol. 12, # 11 p. 2927 - 2936

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Citation Number: 21

Abstract

Nitration of 17β-estradiol by H2O2 and nitrite in the presence of various peroxidases, viz. horseradish peroxidase, lactoperoxidase, and peroxidase-containing homogenates from bovine uteri, was systematically investigated to assess on a chemical basis its potential relevance to the mechanisms of impairment of estrogen functions under oxidative/nitrosative stress conditions. In the presence of excess nitrite 17β-estradiol reacted smoothly to give 2 ...