A new manganese-mediated, cobalt-catalyzed three-component synthesis of (diarylmethyl) sulfonamides

A Pignon, E Le Gall, T Martens

Index: Pignon, Antoine; Le Gall, Erwan; Martens, Thierry Beilstein Journal of Organic Chemistry, 2014 , vol. 10, p. 425 - 431

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Abstract

Abstract The synthesis of (diarylmethyl) sulfonamides and related compounds by a new manganese-mediated, cobalt-catalyzed three-component reaction between sulfonamides, carbonyl compounds and organic bromides is described. This organometallic Mannich-like process allows the formation of the coupling products within minutes at room temperature. A possible mechanism, emphasizing the crucial role of manganese is proposed.

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