Pd/ligand-free synthesis of thienopyranones via Cu-catalyzed coupling-cyclization in PEG 400 under ultrasound
MS Rao, M Haritha, N Chandrasekhar, MVB Rao…
Index: Rao, Manam Sreenivasa; Haritha, Meda; Chandrasekhar; Basaveswara Rao, Mandava V.; Pal, Manojit Tetrahedron Letters, 2014 , vol. 55, # 9 p. 1660 - 1663
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Citation Number: 5
Abstract
Abstract A greener and practical synthesis of 5-substituted thieno [2, 3-c] pyran-7-ones has been achieved via Cu-catalyzed coupling-cyclization of 3-iodothiophene-2-carboxylic acid with terminal alkynes in the presence of K 2 CO 3 in PEG 400 under ultrasound irradiation. A range of thienopyranone derivatives were synthesized by using this inexpensive and Pd- and ligand-free methodology.
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