Helvetica Chimica Acta

Étude comparative de la décarboxylation des acides (benzothiazolyl??2)??acétique,??3??propionique,??glyoxylique et??pyruvique

P Baudet, C Otten

Index: Baudet,P.; Otten,C. Helvetica Chimica Acta, 1970 , vol. 53, p. 1683 - 1693

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Citation Number: 10

Abstract

Abstract Benzothiazol-2-yl glyoxylic acid and α-amino-benzothiazol-2-yl acetic acid hydrochloride undergo decarboxylation at room temperature. This facile decarboxylation seems to depend on the following requirements:(a) the formation of a planar zwitterion;(b) a distance of about 2.2 Å between the charges of the zwitterion;(c) the stabilisation of the intermediate carbanion.