A novel Friedel-Crafts reaction: synthesis of 4-phenylnaphthalen-1-ols

JT Huang, TL Su, KA Watanabe

Index: Huang, Jai-Tung; Su, Tsann-Long; Watanabe, Kyoichi A. Journal of Organic Chemistry, 1991 , vol. 56, # 15 p. 4811 - 4815

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Citation Number: 15

Abstract

Reaction of several benzene derivatives (3b-d) with succinyl chloride (Scheme I) at low temperature afforded the corresponding lactones (5b-d, 17-50%) as the major product, along with small amounts of 1, 2-bis (benzoyl)-ethanes (6b-f, 0.6-9%). It should be noted that we isolated 5b as a major product (50%) along with 6d (8%) when the same reaction was carried out at-5" C. Under very similar conditions (only difference was the temperature, ...

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