Enantioselective synthesis of α-hydroxyketones using the ditox asymmetric building block

PCB Page, M Purdie, D Lathbury

Index: Page, Philip C. Bulman; Purdle, Mark; Lathbury, David Tetrahedron Letters, 1996 , vol. 37, # 49 p. 8929 - 8932

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Citation Number: 18

Abstract

The 2-(R) and 2-(S)-hydroxy-1-phenylbutan-1-ones have been prepared in high enantiomeric excesses and in five steps from propanal using a dithiane oxide unit as an asymmetric building block and a modified Sharpless enantioselective sulphur oxidation as the source of Chirality.