Design, synthesis, and pharmacological profile of novel fused pyrazolo [4, 3-d] pyridine and pyrazolo [3, 4-b][1, 8] naphthyridine isosteres: A new class of potent and …

EJ Barreiro, CA Camara, H Verli…

Index: Dias; Freitas; Barreiro; Goins; Nanayakkara; McChesney Bollettino Chimico Farmaceutico, 2000 , vol. 139, # 1 p. 14 - 20

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Citation Number: 83

Abstract

A new family of tacrine (THA) analogues (7-9, 12), containing the azaheterocyclic pyrazolo [4, 3-d] pyridine or pyrazolo [3, 4-b][1, 8] naphthyridine systems as isosteres of the quinoline ring of THA, has been synthesized. The compounds were tested in rat brain cholinesterases