Reactions of enamines with trifluoroacetic anhydride: trifluoroacetylation and the formation of 1, 3-oxazines

W Verboom, DN Reinhoudt, S Harkema…

Index: Verboom, Willem; Reinhoudt, David N.; Harkema, Sybolt; Hummel, Gerrit J. van Journal of Organic Chemistry, 1982 , vol. 47, # 17 p. 3339 - 3342

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Citation Number: 23

Abstract

(6c) with TFA in THF, however, afforded, after distillation, a mixture of products, of which the minor compound was the trifluoroacetylated compound 7c. After column chromatography (alumina), the major reaction product, a white crystalline compound, was isolated in a yield of 53%. Mass spectrometry and elemental analysis exhibited that a CF3C0 moiety had been introduced, but the absence of a carbonyl group (IR and I3C NMR spectroscopy) ruled