Alkylation and acylation of the 1, 2, 3-triazole ring

S Ohta, I Kawasaki, T Uemura, M YAMASHITA…

Index: Ohta, Shunsaku; Kawasaki, Ikuo; Uemura, Takahiro; Yamashita, Masayuki; Yoshioka, Tomomichi; Yamaguchi, Satoshi Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 7 p. 1140 - 1145

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Citation Number: 17

Abstract

Trimethylsilylaion of 1, 2, 3-triazole regioselectively proceeded to give 2-trimethylsilyl-2H-1, 2, 3-triazole, which was treated with primary alkyl halides in the presence of tetrabutylammonium fluoride to give 1-alkyl-1H-1, 2, 3-triazoles as a sole product. 1-Methyl-5- substituted 1H-1, 2, 3-triazoles were prepared by alkylation of 5-lithio-1-methyl-1H-1, 2, 3- triazole, and 1-methyl-4-substituted 1H-1, 2, 3-triazoles were obtained by alkylaiton of 4- ...

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