Ultra-short-acting. beta.-adrenergic receptor blocking agents. 2.(Aryloxy) propanolamines containing esters on the aryl function

…, CM Woo, WG Anderson, RJ Gorczynski

Index: Erhardt, Paul W.; Woo, Chi M.; Anderson, William G.; Gorczynski, Richard J. Journal of Medicinal Chemistry, 1982 , vol. 25, # 12 p. 1408 - 1412

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Citation Number: 87

Abstract

Several short-acting &adrenergic receptor blocking agents have been prepared by incorporating ester functions into the aryl portion of certain (ary1oxy) propanolamine systems. In particular, methyl 3-[4-[2-hydroxy-3-(isopropyl-amino) propoxy] phenyl] propionate hydrochloride (ASL-8052) was found to be a moderately potent, cardioselective compound with a short duration of action when determined in in vivo canine models.