Synthesis of uridine analogues to probe the functional group requirements of the hairpin ribozyme

…, KJ Young, S Jones, JA Grasby

Index: Vyle, Joseph S.; Young, Karen J.; Jones, Sarah; Grasby, Jane A. Collection of Czechoslovak Chemical Communications, 1996 , vol. 61, p. S280 - S282

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Citation Number: 3

Abstract

Recent improvements in solid phase protocols for RNA synthesis1 have facilitated sitespecific incorporation of modified nucleotides into ribozyme sequences. This has enabled determination of the functional group requirements of several bases found to be essential for catalytic activity2. A comprehensive study of the effect of modified purine residues at conserved sites has already been performed for the hairpin ribozyme3 but ...