3-(4-Methylpiperazino) dibenzo [b, f]-1, 2, 4-triazolo [4, 3-d]-1, 4-thiazepine and its 6-chloro and 12-chloro derivatives; Synthesis and pharmacology

Z Polívka, J Holubek, E Svátek, A Dlabač…

Index: Polivka; Holubek; Svatek; et al. Collection of Czechoslovak Chemical Communications, 1983 , vol. 48, # 5 p. 1465 - 1476

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Citation Number: 5

Abstract

Abstract Dibenzo [b, f]-1, 4-thiazepin-11 (10H)-ones IIa-IIc reacted with phosphorus pentasulfide in pyridine under the formation of the thiones IIIa-IIIc which were transformed by treatment with hydrazine hydrate in 1-butanol to the hydrazine derivatives IVa-IVc. Reactions with triethyl orthoformate in ethanol in the presence of sulfuric acid effected cyclization to dibenzo [b, f]-1, 2, 4-triazolo [4, 3-d]-1, 4-thiazepine (Va) and its chloro derivatives Vb, Vc ...