Copper-Catalyzed Guanidinylation of Aryl Iodides: The Formation of N, N′-Disubstituted Guanidines

M Cortes-Salva, BL Nguyen, J Cuevas…

Index: Cortes-Salva, Michelle; Nguyen, Be-Lan; Cuevas, Javier; Pennypacker, Keith R.; Antilla, Jon C. Organic Letters, 2010 , vol. 12, # 6 p. 1316 - 1319

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Citation Number: 26

Abstract

A copper-catalyzed cross-coupling reaction of guanidine nitrate with aryl iodides was used for the formation of N, N′-disubstituted guanidines to be used as potential therapeutics for strokes. A relatively inexpensive commercially available guanidine salt and a series of aryl iodides together with copper iodide and N, N-diethylsalicylamide as an efficient catalyst/ligand system provided a simple diarylation procedure.