Acylation of ester enolates by N-methoxy-N-methylamides: an effective synthesis of. beta.-keto esters
JA Turner, WS Jacks
Index: Turner, James A.; Jacks, Wendy S. Journal of Organic Chemistry, 1989 , vol. 54, # 17 p. 4229 - 4231
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Citation Number: 61
Abstract
Acylation of ester enolates represents a straightforward method for preparation of@-keto esters. The approach is exemplified by the classic acetoacetic ester synthesis in which esters serve as both nucleophile (as an enolate) and acylating agent.'When the two ester fragments are different, and both contain a-hydrogens, the reaction (in fact, a series of equilibria) is complicated by the inability to control the nucleophilic and electrophilic ...
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