Practical and scalable synthesis of S1P1 receptor agonist ACT-209905

G Schmidt, S Reber, MH Bolli…

Index: Organic Process Research and Development, , vol. 16, # 4 p. 595 - 604

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Citation Number: 8

Abstract

... Instead, an in situ hydrolysis process was devised. ... The final step was carried out similar to the procedure used by our Medicinal Chemists. ... a low onset temperature in DSC as neat substance.(19) Clearly, the standard isolation by evaporation of an organic phase containing ...