Practical preparation of potentially anesthetic fluorinated ethyl methyl ethers by means of bromine trifluoride and other methods
…, JW Reed, F Yan, M Hudlicky, MA Endoma…
Index: Hudlicky, Tomas; Duan, Caiming; Reed, Josephine W.; Yan, Fengyang; Hudlicky, Milos; Endoma, Mary Ann; Eger II, Edmond I. Journal of Fluorine Chemistry, 2000 , vol. 102, # 1-2 p. 363 - 367
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Citation Number: 6
Abstract
Synthetic methods, especially those that use bromine trifluoride as a fluorinating agent, are described for the preparation of a number of fluorinated ethyl methyl ethers in good yield and high purity. In all cases, medium-scale syntheses (8–22g) of potentially anesthetic compounds have been accomplished. The compounds are of sufficient purity (> 99%) for biological evaluation.
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