Synthesis of 6-formyl-pyridine-2-carboxylate derivatives and their telomerase inhibitory activities

S Jew, B Park, D Lim, MG Kim, IK Chung, JH Kim…

Index: Jew, Sang-Sup; Park, Boon-Saeng; Lim, Doo-Yeon; Kim, Myoung Goo; Chung, In Kwon; Kim, Joo Hee; Hong, Chung Il; Kim, Joon-Kyum; Park, Hong-Jun; Lee, Jun-Hee; Park, Hyeung-Geun Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 4 p. 609 - 612

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Citation Number: 30

Abstract

Twenty-one pyridine-2-carboxylate derivatives were prepared by the coupling of 6-formyl-2- carboxylic acid with the corresponding phenol, thiophenol, and aniline, substituted with various functional groups. Among them, the 3, 4-dichlorothiophenol ester (9p) showed the highest in vitro telomerase inhibitory activity and quite significant in vivo tumor suppression activity.