Friedel–Crafts acylation with amides
EK Raja, DJ DeSchepper, SO Nilsson Lill…
Index: Raja, Erum K.; Deschepper, Daniel J.; Nilsson Lill, Sten O.; Klumpp, Douglas A. Journal of Organic Chemistry, 2012 , vol. 77, # 13 p. 5788 - 5793
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Citation Number: 18
Abstract
Friedel–Crafts acylation has been known since the 1870s, and it is an important organic synthetic reaction leading to aromatic ketone products. Friedel–Crafts acylation is usually performed with carboxylic acid chlorides or anhydrides, while amides are generally not useful substrates in these reactions. Despite being the least reactive carboxylic acid derivative, we have found a series of amides capable of providing aromatic ketones in ...
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