The Synthesis of Tenofovir and Its Analogues via Asymmetric Transfer Hydrogenation

Q Zhang, BW Ma, QQ Wang, XX Wang, X Hu…

Index: Zhang, Qian; Ma, Bai-Wei; Wang, Qian-Qian; Wang, Xing-Xing; Hu, Xia; Xie, Ming-Sheng; Qu, Gui-Rong; Guo, Hai-Ming Organic Letters, 2014 , vol. 16, # 7 p. 2014 - 2017

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Citation Number: 13

Abstract

A series of tenofovir analogues with potential antiviral and immunobiologically active compounds were synthesized through an asymmetric transfer hydrogenation reaction from achiral purine derivatives. Up to 97% ee and good to excellent yields were achieved under mild conditions through short reaction steps. The present report suggests an efficient process to acquire tenofovir and its analogues.