Synthesis of Tipranavir Analogues as Non-Peptidic HIV Protease Inhibitors

…, V Prasad, VNS Chamakura, KL Smith…

Index: Ding, Yili; Vara Prasad, Chamakura V.N.S.; Smith, Kenneth L.; Chang, Eugene; Hong, Jian; Yao, Nanhua Letters in Organic Chemistry, 2009 , vol. 6, # 2 p. 130 - 133

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Citation Number: 6

Abstract

An analogue of Tipranavir was designed by replacing the dihydropyrone core with a 1, 3- cyclohexanedione ring. The thio-alkyl group was used as a temporary protection group for α, β-unsaturated cyclohexane-1, 3-diketone derivative, and the resulting compound was reacted with an ethyl-organometallic reagent to form the desired Michael addition product. By using this strategy, a more stable analogue of Tipranavir was synthesized and ...