Synthesis and evaluation of dimeric 1, 2, 3, 4-Tetrahydro-naphthalenylamine and Indan-1-ylamine derivatives with mast cell-stabilising and anti-allergic activity
JW Barlow, JJ Walsh
Index: Barlow, James W.; Walsh, John J. European Journal of Medicinal Chemistry, 2010 , vol. 45, # 1 p. 25 - 37
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Citation Number: 18
Abstract
In a continuation of our studies into 4-Amino-3, 4-dihydro-2H-naphthalen-1-ones as novel modulators of allergic and inflammatory phenomena, we have extended our work to include dimeric analogues. Of these derivatives, the most promising activity was seen with tertiary amine 58a, which exhibited potent mast cell-stabilising activity in vitro against a variety of stimuli and also in vivo against passive cutaneous anaphylaxis.
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