Synthesis and biological activity of 1, 2, 3, 4-tetrahydroquinoline and 3, 4-(1H)-dihydroquinolin-2-one analogs of retinoic acid

…, SM Thacher, T Arefieg, RAS Chandraratna

Index: Beard, Richard L.; Teng, Min; Colon, Diana F.; Duong, Tien T.; Thacher, Scott M.; Arefieg, Taghreed; Chandraratna, Roshantha A.S. Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 18 p. 2373 - 2378

Full Text: HTML

Citation Number: 8

Abstract

Retinoids are natural and synthetic analogs of the hormone retinoic acid. Retinoids are currently being investigated clinically as drugs in several areas, including dermatology and oncology. We report the synthesis and biological activity of a new series of potent, RAR- specific retinoids substituted with a 1, 2, 3, 4-tetrahydroquinoline or a 3, 4-(1H)- dihydroquinolin-2-one group.