Synthetic strategies to 2′-hydroxy-4′-methylsulfonylacetophenone, a key compound for the preparation of flavonoid derivatives
R Gueye, C Pouget, Y Champavier, J Buxeraud…
Index: Gueye, Rokhaya; Pouget, Christelle; Champavier, Yves; Buxeraud, Jacques; Duroux, Jean-Luc; Fagnere, Catherine Comptes Rendus Chimie, 2014 , vol. 17, # 5 p. 443 - 449
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Abstract
Abstract Different strategies for the synthesis of 2′-hydroxy-4′- methylsulfonylacetophenone are reported in the present paper. This compound is considered as a key synthon for the synthesis of new flavonoid derivatives designed as potential cyclooxygenase-2 inhibitors. The retrosynthetic approach via 3′- methylsulfonylacetophenone, which included three synthetic pathways, did not allow us to ...
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