4-Anilino-7, 8-dialkoxybenzo [g] quinoline-3-carbonitriles as potent Src kinase inhibitors

DM Berger, M Dutia, G Birnberg, D Powell…

Index: Berger, Dan M.; Dutia, Minu; Birnberg, Gary; Powell, Dennis; Boschelli, Diane H.; Wang, Yanong D.; Ravi, Malini; Yaczko, Deanna; Golas, Jennifer; Lucas, Judy; Boschelli, Frank Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5909 - 5920

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Citation Number: 18

Abstract

It has been previously reported that appropriately substituted 4-anilinoquinoline-3- carbonitriles are potent inhibitors of Src kinase, with biological activity in vitro and in vivo. Structural modifications to these compounds have been explored, providing the 4- anilinobenzo [g] quinoline-3-carbonitriles as a series with enhanced Src inhibitory properties. The synthesis and structure-activity relationships of these 4-anilino-7, 8- ...